Capital Structure - Summary of Common Stock Reserved for Future Issuance (Detail) - shares	Mar. 31, 2023	Dec. 31, 2022
Class of Stock [Line Items]
Common Stock reserved for future issuance	9,348,507	2,795,645
Two Thousand Fourteen Omnibus Incentive Plan [Member]
Class of Stock [Line Items]
Common Stock reserved for future issuance	1,020	1,317
Two Thousand Twenty One Employment Inducement Plan [Member]
Class of Stock [Line Items]
Common Stock reserved for future issuance	12,375	12,375
Stock Options [Member]
Class of Stock [Line Items]
Common Stock reserved for future issuance	79,661	55,565
Warrants [Member]
Class of Stock [Line Items]
Common Stock reserved for future issuance	7,151,451	2,151,451
CFRX Prefunded Warrants [Member]
Class of Stock [Line Items]
Common Stock reserved for future issuance	2,104,000	574,937