Quarterly report pursuant to Section 13 or 15(d)

Capital Structure - Additional Information (Detail)

v3.23.1
Capital Structure - Additional Information (Detail)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2023
shares
Mar. 02, 2023
USD ($)
$ / shares
shares
Feb. 10, 2023
Dec. 15, 2022
USD ($)
$ / shares
shares
Mar. 22, 2021
USD ($)
$ / shares
shares
May 27, 2020
USD ($)
$ / shares
shares
Jul. 25, 2017
USD ($)
Mar. 31, 2023
USD ($)
shares
Mar. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2020
Class of Stock [Line Items]                      
Common stock, shares authorized | shares               125,000,000      
Number of shares issued | shares           147,471          
Net proceeds received | $           $ 48,900          
Gross Proceed | $           $ 3,000          
Dividends declared or paid | $               $ 0      
Common stock, voting rights               The holders of shares of common stock are entitled to one vote for each share of common stock held at all meetings of stockholders and written actions in lieu of meetings.      
Fair value adjustment of warrants | $               $ (7,400) $ 4,212    
Stockholders' Equity, Reverse Stock Split     1-for-80                
Maximum [Member]                      
Class of Stock [Line Items]                      
Stockholders' Equity, Reverse Stock Split     1-for-80                
Minimum [Member]                      
Class of Stock [Line Items]                      
Stockholders' Equity, Reverse Stock Split     1-for-10                
Other Expense [Member]                      
Class of Stock [Line Items]                      
Fair value adjustment of warrants | $                   $ 4,000  
Private Placement [Member]                      
Class of Stock [Line Items]                      
Issuance of securities in private placement, Shares | shares           8,427          
Follow-on Offering [Member]                      
Class of Stock [Line Items]                      
Public offering price, per unit | $ / shares           $ 356          
Warrants to purchase shares of common stock | shares           110,603          
Warrant exercise price per share | $ / shares           $ 392          
Conversion ratio of common stock                     0.75
Follow-on Offering [Member] | 2020 Warrants [Member]                      
Class of Stock [Line Items]                      
Fair value of warrants | $             $ 31,400        
Issuance costs allocated to warrants | $             $ 2,200        
Follow-on Offering [Member] | 2022 Warrants [Member]                      
Class of Stock [Line Items]                      
Fair value of warrants | $           $ 11,000          
Issuance costs allocated to warrants | $           $ 900          
Over-Allotment Option [Member]                      
Class of Stock [Line Items]                      
Number of shares issued | shares         143,750            
Public offering price, per unit | $ / shares         $ 400            
Sale of stock, price per share | $ / shares         $ 400            
Proceeds from Issuance Initial Public Offering | $         $ 53,800            
Class A Warrant and Class B Warrant [Member]                      
Class of Stock [Line Items]                      
Sale of stock, price per share | $ / shares       $ 10.32              
Pre Funded Warrants and Common Stock [Member]                      
Class of Stock [Line Items]                      
Proceeds from issuance or sale of equity | $   $ 9,100   $ 6,100              
Two Thousand And Twenty Two Offering [Member]                      
Class of Stock [Line Items]                      
Warrant exercise price per share | $ / shares   $ 4   $ 10.32              
Sale of stock, price per share | $ / shares       $ 10.32              
Class of warrant purchase percentage   4.00%                  
Proceeds from issuance or sale of equity | $   $ 9,100                  
Number of common stock Called by each warrant or right | shares   2                  
Stockholders' Equity, Reverse Stock Split     1-for-80                
Pfizer Warrants [Member]                      
Class of Stock [Line Items]                      
Warrants to purchase shares of common stock | shares           6,320          
Warrant exercise price per share | $ / shares           $ 392          
Pre-Funded Warrants                      
Class of Stock [Line Items]                      
Stock Issued During Period, Shares, Acquisitions | shares 268,000                    
Pre-Funded Warrants | Two Thousand And Twenty Two Offering [Member]                      
Class of Stock [Line Items]                      
Number of common stock Called by each warrant or right | shares   1                  
Class A warrants [Member] | Two Thousand And Twenty Two Offering [Member]                      
Class of Stock [Line Items]                      
Number of common stock Called by each warrant or right | shares       2              
Class B warrants [Member] | Two Thousand And Twenty Two Offering [Member]                      
Class of Stock [Line Items]                      
Number of common stock Called by each warrant or right | shares       1              
CFRX Prefunded Warrants [Member] | Follow-on Offering [Member]                      
Class of Stock [Line Items]                      
Warrants to purchase shares of common stock | shares 623,919             623,919