Commitments and Contingencies - Additional Information (Detail) |
1 Months Ended | 12 Months Ended | ||||||
|---|---|---|---|---|---|---|---|---|
Apr. 02, 2019 |
Jan. 31, 2012
ft²
ExtensionOptions
|
Dec. 31, 2011
ExtensionOptions
|
Dec. 31, 2010 |
Dec. 31, 2020
USD ($)
|
Dec. 31, 2019
USD ($)
|
Dec. 31, 2018
USD ($)
|
Jan. 01, 2019 |
|
| Loss Contingencies [Line Items] | ||||||||
| Non-cancellable operating lease, expiration date | 2027-12 | 2025-12 | ||||||
| Extended lease agreement, date | 2027-12 | |||||||
| Number of lease extension options | ExtensionOptions | 2 | 2 | ||||||
| Lease renewal termination period | 5 years | 5 years | ||||||
| Area of space relinquished from lease agreement | ft² | 10,912 | |||||||
| Rent expense | $ 618,000 | |||||||
| Milestone payment | $ 810,000 | |||||||
| Operating lease, remaining lease term | 9 years | |||||||
| Operating lease, discount rate, percent | 9.93% | |||||||
| Gilman [Member] | Separation Agreements [Member] | ||||||||
| Loss Contingencies [Line Items] | ||||||||
| Percentage of bonus on last drawn salary | 25.00% | |||||||
| Rockefeller University [Member] | ||||||||
| Loss Contingencies [Line Items] | ||||||||
| Annual maintenance fees payable in 2018 | 200,000 | $ 200,000 | ||||||
| Annual maintenance fees payable after 2018 | $ 200,000 | $ 200,000 | ||||||
| Percentage of royalty on net sales | 5.00% | 5.00% | ||||||
| Milestone payment | $ 430,000 | |||||||
| Royalty or sublicense payment | $ 0 | $ 0 | ||||||
| License agreement termination notice period | 60 days | |||||||
| Period of termination after first commercial sale of first licensed product | 10 years | |||||||
| License agreement termination description | Each license agreement terminates upon the later of (i) the expiration or abandonment of the last licensed patent under the license agreement to expire or become abandoned, or (ii) 10 years after the first commercial sale of the first licensed product. The Rockefeller University may terminate any license agreement in the event of a breach of such agreement by the Company or if the Company challenges the validity or enforceability of the underlying patent rights. The Company may terminate any license agreement at any time on 60 days’ notice. | |||||||